tissue factor การใช้

• Currently, recombinant tissue factor is not available and used in some PT assays.
• Normal coagulation is initiated by the release of tissue factor from damaged tissue.
• The best known function of tissue factor is its role in blood coagulation.
• Surgery anywhere in the body exposes something called tissue factor which can increase coagulation.
• Tissue factor is not needed to activate the intrinsic pathway.
• It may also enhance coagulation by inhibiting the function of tissue factor pathway inhibitor.
• However, partial thromboplastin is just phospholipids, and not tissue factor.
• Tissue factor is found on the outside of blood vessels-normally not exposed to the bloodstream.
• Together with factor VIIa, tissue factor forms the tissue factor or extrinsic pathway of coagulation.
• Together with factor VIIa, tissue factor forms the tissue factor or extrinsic pathway of coagulation.
• Phospholipid is available as an independent reagent or in combination with tissue factor as thromboplastin.
• Many trauma patients suffer from an overwhelming activation of tissue factor and thus massive hyperfibrinolysis.
• Factor VII has been shown to interact with tissue factor . Also reacts with protein kinase C.
• Tissue factor binds to circulating factor VIIa.
• The process is thought to be initiated by tissue factor-affected thrombin production, which leads to fibrin deposition.
• One critical mediator of DIC is the release of a transmembrane glycoprotein called tissue factor ( TF ).
• The N-terminal EGF domain has been shown to at least in part be responsible for binding tissue factor.
• Various mechanisms, such as deficiency of protein S and tissue factor pathway inhibitor, are said to be responsible.
• Ixolaris, a tissue factor inhibitor has been shown to block primary tumour growth and angiogenesis in a glioblastoma model.
• The theory that thrombin is generated by the presence of tissue factor was consolidated by Paul Morawitz in 1905.